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	Provedor de dados Genet. Mol. Biol. (2) Autor Cussiol,José Renato Rosa (1) Hoch,Nicolas C. (1) Oliveira,Francisco Meirelles Bastos de (1) Polo,Luis M. (1) Soares,Bárbara Luísa (1) Palavra-chave DNA damage response (2) ADP ribose (1) Cell cycle checkpoint (1) DNA repair (1) Genome instability (1) Kinase (1) PARP (1) Parthanatos (1) Yeast (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última ADP-ribosylation: from molecular mechanisms to human disease Genet. Mol. Biol. Hoch,Nicolas C.; Polo,Luis M.. Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. Tipo: Info:eu-repo/semantics/article Palavras-chave: ADP ribose; PARP; DNA damage response; DNA repair; Parthanatos. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304 From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases Genet. Mol. Biol. Cussiol,José Renato Rosa; Soares,Bárbara Luísa; Oliveira,Francisco Meirelles Bastos de. Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast... Tipo: Info:eu-repo/semantics/article Palavras-chave: Yeast; Genome instability; DNA damage response; Cell cycle checkpoint; Kinase. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200302 Registros recuperados: 2 Primeira ... 1 ... Última

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